peptide 401 Studies on histamine release induced by compound 48/80 and peptide 401 - what-energy-drives-formation-of-peptide-bind-in-ribosome is a minor component of honeybee venom Unveiling Peptide 401: A Potent Factor from Bee Venom with Anti-inflammatory Properties

peptide-57 Peptide 401, scientifically identified by its CAS Number 32908-73-9, is a fascinating polypeptide with 22 amino acid residues that has garnered significant research interest due to its potent biological activities. Primarily isolated from bee venom, this mast cell degranulating peptide (also known as MCD peptide) exhibits a range of effects, most notably its anti-inflammatory capabilitiesPeptide 401. Understanding the properties and applications of peptide 401 is crucial for researchers and scientists exploring natural compounds for therapeutic interventions.

The chemical structure of Peptide 401 is complex, with a linear formula of C110H192N40O24S and a molecular weight of approximately 2587.22 grams per mole. Its molecular structure bears resemblance to apamin, another component of honeybee venom, and it features two disulfide bridges. This structural characteristic contributes to its stability and biological function.Peptide 401, a potentmastcell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various ... While often referred to as Peptide 401, it is also known by other identifiers such as MCD peptide and Mast Cell Degranulating Peptide.

One of the most well-documented functions of Peptide 401 is its ability to induce mast cell degranulation. Mast cells are critical immune cells involved in inflammatory and allergic responsesAnti-inflammatory activity of bee venom peptide 401 (mast .... By triggering the release of histamine and other mediators from these cells, Peptide 401 plays a direct role in initiating an inflammatory cascade. However, paradoxically, at certain concentrations, it also demonstrates significant anti-inflammatory propertiesPeptide 401 | 32908-73-9. Studies have shown that Peptide 401 can suppress the increased vascular permeability induced by various agents, a hallmark of inflammation. This effect is attributed, at least partially, to its ability to inhibit prostaglandin synthesis.

The anti-inflammatory activities of Peptide 401 have been extensively studied.Who Should NOT Take Peptides? - SynergenX Health Research indicates that its effects are mediated by mast cell degranulation, and in some experimental models, these activities were partially suppressed by pretreatment with specific antagonists, suggesting a complex interplay with histamine receptors. For instance, studies involving histamine receptor antagonists have provided insights into the mechanisms by which Peptide 401 exerts its influence. Furthermore, it has been observed to substantially inhibit edema provoked by subplantar injection of carrageenin, a common model for studying inflammation.Five Types of Skin-Repairing Peptides - Prospector Knowledge Center

The storage and handling of Peptide 401 are important considerations for maintaining its integrity and efficacyPeptide 401 – 美仑生物. In lyophilized form, it is typically stable for up to 6 months at 0-5°C. For optimal results, it is recommended to rehydrate the peptide just before use, and after rehydration, the solution can be stored at +4°C for up to 5 days. For longer-term storage of the rehydrated solution, -20°C for 6 months or -80°C for 1 year are suggested. It's important to note that most peptides are stable for approximately 3-6 months after rehydration, particularly those containing sensitive amino acid residues like Tryptophane, Cystein, and Methionine.Peptide 401

While the primary focus of Peptide 401 research has been its anti-inflammatory and mast cell degranulating properties, it is also recognized as a potent antimicrobial peptide (AMP).作者：Y Chen·被引用次数：1—The conjugate is intended toactivate in response to reactive oxygen species (ROS) and release carbon monoxide (CO) to address the elevated ROS ... AMPs are a vital part of the innate immune system and play a role in defending against a wide range of pathogens. The antimicrobial nature of Peptide 401 opens up further avenues for investigation into its potential therapeutic applications.ANTI‐INFLAMMATORY PROPERTY OF ...

In the realm of scientific research, Peptide 401 is often supplied in specific quantities, such as 1x0.5 mg. The quality standard for this peptide is typically greater than 98% purity.作者：NV Kumar·1988·被引用次数：27—P401 (also known as mast cell degranulating protein, MCD)is a minor component of honeybee venom. Its primary structure is related to that of apamin. Its CAS Number, 32908-73-9, serves as a unique identifier for procurement and research purposes.

Beyond its direct biological effects, Peptide 401 also intersects with broader scientific discussions.Anti-inflammatory activity of bee venom peptide 401 (mast ... For example, research into arginine-rich peptides highlights their role in cell penetration, and studies on Hyaluronan mediated motility receptor 393-401 delve into cellular signaling pathways. Furthermore, the development of advanced therapeutic strategies, such as multifunctional peptide-drug conjugates like Corm-401@R9, which are designed to activate in response to reactive oxygen species (ROS), demonstrates the evolving landscape of peptide-based research.

In summary, Peptide 401 stands out as a significant compound derived from bee venom, recognized for its potent mast cell degranulating and anti-inflammatory activities. Its well-defined chemical structure, coupled with its diverse biological functions, makes it a valuable subject for ongoing scientific exploration, particularly in the fields of immunology, inflammation research, and potentially antimicrobial therapies.